Biography
Biography: Anthony Jones
Abstract
Pain is one of the main drivers of long term disability in patients with chronic musculoskeletal pain. The matrix of brain structures responsible for the perception of pain has been shown to have both high specificity and sensitivity for pain. Subtle sex differences in cortical processing have also been described. There is increasing evidence for central sensitization resulting from abnormal processing within this matrix being a key driver in the maintenance of chronic pain. Common candidate mechanisms related to abnormal processing of expectation and attention to pain have been identified in the brains of patients with osteoarthritis (OA) and fibromyalgia (FM). Increased summation and abnormalities of descending inhibition have also been identified in these populations. In addition changes in brain opioid receptor binding have been related to increased vulnerability and vulnerability to pain. These findings taken together suggest a range of physiological phenotypes in patients with different types of chronic pain that does not respect traditional medical models and classifications of pain.
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