Hang Liu
1st Hospital of China Medical University
China
Title: Retroperitoneal fibrosis：A clinical and outcome analysis of 81 cases and review of literature
Biography
Biography: Hang Liu
Abstract
Objective To investigate the clinical features and outcomes of retroperitoneal fibrosis (RPF). Methods 81 RPF treatment cases in the First Affiliated Hospital of China Medical University were retrospectively analyzed, including clinical characteristics and laboratory data. Results RPF was found predominantly in elderly men with atypical clinical manifestations of back pain, abdominal pain and lower limb edemas. In laboratory examinations, the acute-phase reactants such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels increased significantly. Renal function failure was frequently found in patients with urethral obstruction. All patients had retroperitoneal soft tissue shadows or urethral obstructions on computed tomography or magnetic resonance imaging, 8 of which had histological diagnosis of idiopathic RPF. 46 patients received surgical interventions; 50 patients received medication treatment alone including corticosteroids, immunosuppressants, and tamoxifen; 21 patients received corticosteroids after surgical intervention. Surgery followed by medication was most effective for RPF. Conclusion Computed tomography and magnetic resonance imaging helps to exclude secondary causes, but biopsy remains the gold standard for diagnosis. Long-term low dose corticosteroids and immunosuppressants may prevent relapse of RPF.