8th International Conference of Orthopedic Surgeons and Rheumatology

Biography

Yuxian Shen’s current research focused on the involvement of endoplasmic reticulum (ER) stress in the pathogenesises of neurodegenerative diseases and inflammatory diseases. The major findings in her lab are the results of protein degradation mediated by ER ubiquitin ligases of Hrd1 and gp78. Both of them facilitate degradation and enhance solubility of a-1-antitrypsin Z mutant, a major cause of a-1-antitrypsin deficiency. They also found that Hrd1 plays an important role in neuron protection. Additionally, Hrd1 promotes hyperphosphorylated tau degradation. An area of Shen’s lab is about ER stress-upregulated protein MANF. They found that MANF is sensitive to ischemia/hypoxia and inflammation. The results suggest that MANF may be involved in neuroprotection and inflammatory inhibition. Further efforts are directed to understand the transcription regulation of MANF under inflammation and ischemia. A new direction in her lab is to investigate the mechanisms of ER stress involved in autoimmune diseases including SLE and RA. 

Abstract

Abstract : The role of Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) in inflammatory arthritis