Orthopedic Surgeons and Rheumatology

Autoinflammatory Diseases

Autoinflammatory diseases are a comparatively new kind of diseases that are different from autoimmune diseases. Autoinflammatory diseases are produced by genetic mutations in molecules that are involved in regulating the innate immune response-a "hard wired" defense system that evolved to quickly recognize and act against infectious agents and other danger signals produced by our bodies. Freshly, the increased knowledge in the field of auto inflammation highlighted shared immune mechanisms in the pathogenesis of both classical monogenetic and multifactorial auto inflammatory diseases and a broad spectrum of chronic age-related inflammatory pathologies. The current growth in the prevalence of chronic inflammatory diseases makes this subject of topical interest.