Orthopedic Surgeons and Rheumatology

Serum sickness

Serum sickness in humans is a reaction to proteins in antiserum derived from a non-human animal source, occurring 5–10 days when exposure. Symptoms typically include a rash, joint pain, fever, and lymphadenopathy. It's a kind of hypersensitivity, specifically immune advanced hypersensitivity (type III). The term serum sickness–like reaction (SSLR) is sometimes used to check with similar diseases that arise from the introduction of certain non-protein substances, like penicillin.

Serum sickness could also be diagnosed supported the symptoms, and using a blood {test|biopsy} and a urine test. It's going to be prevented by not using an antibody derived from animal serum, and through prophylactic antihistamines or corticosteroids. It always resolves naturally, however could also be treated with corticosteroids, antihistamines, analgesics, and (in severe cases) prednisone. It absolutely was 1st characterised in 1906.